ALCAM

Across TCGA pan-cancer cohorts, ALCAM mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ALCAM’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ALCAM mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ALCAM is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where ALCAM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALCAM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.564	<.001	9	view →
CCRCC	All	II,III,IV	−0.320	<.001	7	view →
LUAD	Male	All	−0.263	<.001	6	view →
PDAC	Female	All	−0.641	<.001	4	view →
LSCC	Female	All	−0.366	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ALCAM–COAD

Open the COAD breakdown →