ALCAM

Across TCGA patient cohorts, ALCAM mutation is significantly associated with the RNA expression of many other genes, with 4,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALCAM-associated genes across cancer lineages are RPL30P12, RN7SL134P, and RN7SL578P. Each is linked with ALCAM in more than 2 cancer types. Because this analysis shows association rather than direction, both ALCAM-to-partner and partner-to-ALCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL30P12 grouped by ALCAM-low versus ALCAM-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALCAM→partner) and Y-score (partner→ALCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL30P12 →	+0.180	+4.137	<.001	.001	3	3
UCEC	RN7SL134P →	+0.093	+2.014	.001	.001	3	3
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
UCEC	FGD5 →	-0.486	-2.153	.005	.003	3	2
UCEC	NTAQ1 →	+0.427	+2.542	.001	<.001	3	2
UCEC	BOLA3 →	+0.435	+1.879	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,122 associations by consensus.

RPL30P12 by ALCAM expression — LUAD

Explore this box plot interactively →