ALCAM

Across TCGA patient cohorts, ALCAM mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALCAM-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and eIF4E. Each is linked with ALCAM in more than 1 cancer types. Because this analysis shows association rather than direction, both ALCAM-to-partner and partner-to-ALCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ALCAM-low versus ALCAM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALCAM→partner) and Y-score (partner→ALCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.307	+1.874	.004	.002	3	2
UCEC	14-3-3_beta →	-0.077	-1.780	.022	.024	3	1
UCEC	eIF4E →	+0.178	+3.472	.011	.002	3	1
UCEC	ACC_pS79 →	+0.273	+1.495	.018	.034	3	1
UCEC	ACC1 →	+0.258	+1.887	.034	.029	3	1
UCEC	JNK2 →	+0.293	+2.201	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

p62 Lck ligand by ALCAM expression — UCEC

Explore this box plot interactively →