ALCAM

Across TCGA cell cohorts, ALCAM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,812 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ALCAM-associated GO terms across cancer lineages are Axon extension involved in axon guidance, Retinal ganglion cell axon guidance, and Positive regulation of chemotaxis. Each is linked with ALCAM in more than 12 cancer types. Because this analysis shows association rather than direction, both ALCAM-to-partner and partner-to-ALCAM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Axon extension involved in axon guidance grouped by ALCAM-low versus ALCAM-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALCAM→partner) and Y-score (partner→ALCAM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Axon extension involved in axon guidance →	+1.147	+1.311	<.001	<.001	3	13
BONE	Retinal ganglion cell axon guidance →	+0.585	+2.899	.006	<.001	3	12
OVARY	Positive regulation of chemotaxis →	+0.086	+1.840	<.001	<.001	3	10
SKIN	Regulation of intracellular transport →	+0.056	+1.853	.002	.007	3	10
SKIN	Endothelial cell fate commitment →	+0.161	+1.870	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Membrane assembly →	+0.113	+1.601	.004	.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,812 associations by consensus.

Axon extension involved in axon guidance by ALCAM expression — BLOOD_Leukemia

Explore this box plot interactively →