ALAS2

Across TCGA patient cohorts, ALAS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,367 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ALAS2-associated GO terms across cancer lineages are Nitric oxide transport, Carbon dioxide transport, and Oxygen transport. Each is linked with ALAS2 in more than 24 cancer types. Because this analysis shows association rather than direction, both ALAS2-to-partner and partner-to-ALAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nitric oxide transport grouped by ALAS2-low versus ALAS2-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAS2→partner) and Y-score (partner→ALAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Nitric oxide transport →	+0.258	+3.156	<.001	<.001	3	25
LAML	Carbon dioxide transport →	+0.290	+3.469	<.001	<.001	3	20
LAML	Oxygen transport →	+0.215	+3.507	<.001	<.001	3	17
MESO	Reactive nitrogen species metabolic process →	+0.039	+0.439	<.001	<.001	3	16
LAML	Hydrogen peroxide catabolic process →	+0.114	+2.717	<.001	<.001	3	16
LAML	Response to reactive oxygen species →	+0.029	+1.734	<.001	<.001	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,367 associations by consensus.

Nitric oxide transport by ALAS2 expression — LAML

Explore this box plot interactively →