ALAS2

Across TCGA patient cohorts, ALAS2 mutation is significantly associated with the RNA expression of many other genes, with 3,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALAS2-associated genes across cancer lineages are MIR588, CDKN2AIPNLP2, and KIR3DL1. Each is linked with ALAS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALAS2-to-partner and partner-to-ALAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR588 grouped by ALAS2-low versus ALAS2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAS2→partner) and Y-score (partner→ALAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR588 →	+0.333	+5.096	<.001	.002	3	3
SKCM	CDKN2AIPNLP2 →	+0.072	+2.815	<.001	.006	3	3
UCEC	KIR3DL1 →	+0.138	+2.273	.003	<.001	3	3
BLCA	RNU6-792P →	+0.230	+4.859	<.001	.004	3	2
HNSC	RNU6-862P →	+0.448	+5.826	<.001	<.001	3	2
HNSC	RNA5SP158 →	+0.303	+5.221	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,863 associations by consensus.

MIR588 by ALAS2 expression — READ

Explore this box plot interactively →