ALAS2

Across TCGA cell cohorts, ALAS2 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALAS2-associated genes across cancer lineages are MYL10, IFITM5, and GRIFIN. Each is linked with ALAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALAS2-to-partner and partner-to-ALAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYL10 grouped by ALAS2-low versus ALAS2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAS2→partner) and Y-score (partner→ALAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MYL10 →	+1.218	+4.963	<.001	.001	3	2
LUNG_SCLC	IFITM5 →	+0.101	+3.459	.006	.008	3	1
CNS	GRIFIN →	+0.082	+5.754	<.001	.002	3	1
LARGE_INTESTINE	CLUAP1 →	+0.679	+3.215	.004	.009	3	1
LARGE_INTESTINE	SFTPB →	+0.171	+2.770	<.001	.004	3	1
LARGE_INTESTINE	TSGA13 →	+0.140	+2.672	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

MYL10 by ALAS2 expression — BREAST

Explore this box plot interactively →