ALAS1

Across TCGA patient cohorts, ALAS1 RNA expression is significantly associated with the mutation status of many other genes, with 8,480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALAS1-associated genes across cancer lineages are DNAH7, OBSCN, and AHNAK. Each is linked with ALAS1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ALAS1-to-partner and partner-to-ALAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAH7 grouped by ALAS1-low versus ALAS1-high in COAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAS1→partner) and Y-score (partner→ALAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DNAH7 →	+1.933	+0.385	.008	<.001	3	6
LIHC	OBSCN →	+2.408	+0.728	<.001	<.001	3	6
STAD	AHNAK →	+3.716	+0.427	<.001	.003	3	6
CESC	TP53 →	+2.532	+0.580	<.001	<.001	3	5
STAD	MUC16 →	+1.124	+0.351	<.001	<.001	3	5
STAD	AHNAK2 →	+2.086	+0.397	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,480 associations by consensus.

DNAH7 by ALAS1 expression — COAD

Explore this box plot interactively →