ALAS1

Across TCGA cell cohorts, ALAS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,882 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALAS1-associated GO terms across cancer lineages are Hemoglobin metabolic process, Hemoglobin biosynthetic process, and Response to hepatocyte growth factor. Each is linked with ALAS1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ALAS1-to-partner and partner-to-ALAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hemoglobin metabolic process grouped by ALAS1-low versus ALAS1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAS1→partner) and Y-score (partner→ALAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Hemoglobin metabolic process →	+0.334	+0.764	<.001	<.001	3	17
BREAST	Hemoglobin biosynthetic process →	+0.314	+0.801	.003	.001	2	15
URINARY_TRACT	Response to hepatocyte growth factor →	+0.146	+0.921	.003	.006	3	9
BREAST	Positive regulation of early endosome to late endosome transport →	+0.159	+1.063	<.001	.001	3	9
BREAST	Positive regulation of store-operated calcium channel activity →	+0.094	+1.060	.001	<.001	3	8
LUNG_NSCLC_LUAD	Tricarboxylic acid cycle →	+0.077	+0.612	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,882 associations by consensus.

Hemoglobin metabolic process by ALAS1 expression — SKIN

Explore this box plot interactively →