ALAS1

Across TCGA cell cohorts, ALAS1 mutation is significantly associated with the RNA expression of many other genes, with 276 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALAS1-associated genes across cancer lineages are CYP11B1, RTP3, and PRAMEF10. Each is linked with ALAS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALAS1-to-partner and partner-to-ALAS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP11B1 grouped by ALAS1-low versus ALAS1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAS1→partner) and Y-score (partner→ALAS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CYP11B1 →	+0.015	+4.169	<.001	.001	3	1
LUNG_SCLC	RTP3 →	+0.017	+3.817	.002	.004	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1
LUNG_SCLC	SULT1C3 →	+0.161	+3.523	.003	.008	3	1
LUNG_SCLC	PRAMEF17 →	+0.008	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF25 →	+0.134	+3.523	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 276 associations by consensus.

CYP11B1 by ALAS1 expression — LUNG_SCLC

Explore this box plot interactively →