ALAD

Across TCGA patient cohorts, ALAD mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALAD-associated genes across cancer lineages are Ku80, MEK1, and PKC-delta_pS664. Each is linked with ALAD in more than 1 cancer types. Because this analysis shows association rather than direction, both ALAD-to-partner and partner-to-ALAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ALAD-low versus ALAD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALAD→partner) and Y-score (partner→ALAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.285	+3.013	.012	.018	3	1
UCEC	MEK1 →	+0.412	+2.459	.019	.020	3	1
UCEC	PKC-delta_pS664 →	-0.137	-2.999	.018	.035	3	1
UCEC	VEGFR2 →	+0.295	+3.009	.040	.019	3	1
UCEC	SLC1A5 →	-0.552	-3.162	.017	.019	2	1
UCEC	VHL →	-0.837	-3.000	.010	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by ALAD expression — UCEC

Explore this box plot interactively →