Across TCGA pan-cancer cohorts, AKT3-IT1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AKT3-IT1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AKT3-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKT3-IT1 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.
HNSC, UCEC, and BRCA are the cancer types where AKT3-IT1 tumor–normal differential expression is most reproducible.