AKT2

Across TCGA pan-cancer cohorts, AKT2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated AKT2 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AKT2 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated AKT2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and LUSC are the cancer types where AKT2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.437	.012	30	view →
HNSC	OS	Median	All	0.138	0.710	.001	24	view →
LUSC	OS	Median	II,III,IV	0.031	0.733	<.001	18	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
BLCA	DFS	Median	III,IV	0.197	0.574	.029	6	view →
KIRP	OS	Median	All	0.192	0.705	.015	4	view →
SKCM	OS	Median	III,IV	0.515	0.847	.002	3	view →
LUAD	OS	Median	All	0.440	0.837	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

AKT2–UCEC (DFS)

Open the UCEC breakdown →