Across TCGA pan-cancer cohorts, AKT1S1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AKT1S1 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AKT1S1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AKT1S1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, UCEC, and PDAC are the cancer types where AKT1S1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.886	0.303	.007	40	view →
UCEC	DFS	Tertile	II,III,IV	0.462	0.926	.009	36	view →
PDAC	OS	Quartile	III,IV	0.547	1.000	.022	19	view →
LSCC	OS	Median	All	0.793	1.000	.025	1	view →
CCRCC	OS	Tertile	All	0.762	0.919	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: AKT1S1 tumor-vs-normal RNA expression · all AKT1S1 data types