Across TCGA pan-cancer cohorts, AKT1S1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of AKT1S1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AKT1S1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AKT1S1 is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, CCRCC, and PDAC are the cancer types where AKT1S1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKT1S1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.326	<.001	11	view →
CCRCC	Female	All	+0.321	<.001	11	view →
PDAC	All	II,III,IV	+0.332	<.001	5	view →
HNSC	All	All	−0.097	.023	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: AKT1S1 RNA expression & survival · all AKT1S1 data types