AKR7A3

Across TCGA pan-cancer cohorts, AKR7A3 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AKR7A3 data layer compared with 19 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher AKR7A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AKR7A3 expression acts as an unfavorable survival marker.

LUAD, LIHC, and SKCM are the cancer types where AKR7A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.176	0.835	<.001	9	view →
LIHC	DFS	Median	All	0.101	0.526	.047	3	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AKR7A3–LUAD (OS)

Open the LUAD breakdown →