AKR7A3

Across TCGA patient cohorts, AKR7A3 protein abundance is significantly associated with the RNA expression of many other genes, with 13,862 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AKR7A3-associated genes across cancer lineages are AKR7L, TFF3, and MAPK3. Each is linked with AKR7A3 in more than 6 cancer types. Because this analysis shows association rather than direction, both AKR7A3-to-partner and partner-to-AKR7A3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKR7A3 versus AKR7L in BRCA, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7A3→partner) and Y-score (partner→AKR7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKR7L →	+1.264	+1.534	<.001	<.001	3	7
BRCA	TFF3 →	+3.776	+1.221	<.001	<.001	3	6
BRCA	MAPK3 →	+0.657	+1.007	<.001	<.001	3	5
PDAC	PFKFB2 →	+0.809	+0.745	<.001	<.001	3	5
COAD	ADAM19 →	-1.009	-0.691	<.001	<.001	3	5
COAD	PAFAH2 →	+0.569	+0.464	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,862 associations by consensus.

AKR7A3 vs AKR7L — BRCA

Explore this scatter interactively →