AKR7A3

Across TCGA patient cohorts, AKR7A3 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR7A3-associated genes across cancer lineages are STAT3_pY705 and XBP1. Each is linked with AKR7A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR7A3-to-partner and partner-to-AKR7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by AKR7A3-low versus AKR7A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7A3→partner) and Y-score (partner→AKR7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.403	-3.169	.005	.020	3	1
UCEC	XBP1 →	-0.245	-2.986	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

STAT3_pY705 by AKR7A3 expression — UCEC

Explore this box plot interactively →