AKR7A3

Across TCGA cell cohorts, AKR7A3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKR7A3-associated genes across cancer lineages are OR6B2, SPEM3, and POU5F2. Each is linked with AKR7A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR7A3-to-partner and partner-to-AKR7A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B2 grouped by AKR7A3-low versus AKR7A3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7A3→partner) and Y-score (partner→AKR7A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR6B2 →	+0.047	+4.054	<.001	.004	3	1
LARGE_INTESTINE	SPEM3 →	+0.016	+4.347	<.001	.001	3	1
LARGE_INTESTINE	POU5F2 →	+0.048	+3.793	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR6B2 by AKR7A3 expression — LARGE_INTESTINE

Explore this box plot interactively →