Across TCGA pan-cancer cohorts, AKR7A2P2 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AKR7A2P2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AKR7A2P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKR7A2P2 is over-expressed in tumor, although a few such as STAD and THCA show the opposite, repressed pattern.

COAD, STAD, and THCA are the cancer types where AKR7A2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR7A2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.323	.001	5	view →
STAD	Male	IV	−0.105	.002	4	view →
THCA	All	II,III,IV	−0.096	.011	4	view →
LUSC	Male	II,III,IV	+0.073	.029	2	view →
BRCA	All	All	−0.030	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: AKR7A2P2 RNA expression & survival · all AKR7A2P2 data types