AKR1E2

Across TCGA patient cohorts, AKR1E2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1E2-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and FoxM1. Each is linked with AKR1E2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1E2-to-partner and partner-to-AKR1E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by AKR1E2-low versus AKR1E2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1E2→partner) and Y-score (partner→AKR1E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.081	+2.000	.016	.032	3	2
UCEC	EGFR_pY1068 →	-0.257	-2.000	.023	.032	3	1
UCEC	FoxM1 →	+0.460	+3.807	<.001	<.001	3	1
UCEC	INPP4B →	-0.325	-2.321	.025	.033	3	1
UCEC	JNK_pT183_Y185 →	-0.192	-3.169	.011	.019	3	1
UCEC	JNK2 →	+0.304	+3.196	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

c-Met_pY1235 by AKR1E2 expression — UCEC

Explore this box plot interactively →