AKR1E2

Across TCGA cell cohorts, AKR1E2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,482 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible AKR1E2-associated GO terms across cancer lineages are RNA localization, Viral translational termination-reinitiation, and Negative regulation of calcium ion export across plasma membrane. Each is linked with AKR1E2 in more than 5 cancer types. Because this analysis shows association rather than direction, both AKR1E2-to-partner and partner-to-AKR1E2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA localization grouped by AKR1E2-low versus AKR1E2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1E2→partner) and Y-score (partner→AKR1E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNA localization →	+0.054	+1.375	.001	<.001	3	6
PANCREAS	Viral translational termination-reinitiation →	+0.052	+1.029	.001	.006	3	6
SKIN	Negative regulation of calcium ion export across plasma membrane →	+0.048	+1.074	.009	.006	3	6
URINARY_TRACT	Response to glycine →	-1.416	-1.794	<.001	<.001	3	5
SKIN	Negative regulation of syncytium formation by plasma membrane fusion →	+0.066	+1.069	<.001	.002	3	5
STOMACH	Poly(A)+ mRNA export from nucleus →	+0.083	+1.206	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,482 associations by consensus.

RNA localization by AKR1E2 expression — PANCREAS

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