AKR1E2

Across TCGA cell cohorts, AKR1E2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,574 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKR1E2-associated genes across cancer lineages are AKR1A1, MAML3, and TCIM. Each is linked with AKR1E2 in more than 9 cancer types. Because this analysis shows association rather than direction, both AKR1E2-to-partner and partner-to-AKR1E2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKR1E2 versus AKR1A1 in LUNG_SCLC, with a Pearson correlation of 0.66.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1E2→partner) and Y-score (partner→AKR1E2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AKR1A1 →	+1.153	+2.011	<.001	<.001	3	10
LUNG_SCLC	MAML3 →	+1.747	+1.990	<.001	<.001	3	6
LUNG_NSCLC_LUSC	TCIM →	+2.578	+2.250	.002	.002	3	5
OESOPHAGUS	C11orf68 →	-1.202	-1.424	<.001	.008	3	5
UPPER_AERODIGESTIVE_TRACT	BCL7A →	+1.305	+1.994	<.001	.001	3	5
LUNG_SCLC	ARFGEF3 →	+2.151	+2.046	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,574 associations by consensus.

AKR1E2 vs AKR1A1 — LUNG_SCLC

Explore this scatter interactively →