AKR1D1

Across TCGA pan-cancer cohorts, AKR1D1 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated AKR1D1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AKR1D1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated AKR1D1 expression acts as an unfavorable survival marker.

HNSC are the cancer types where AKR1D1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.446	0.921	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

AKR1D1–HNSC (DFS)

Open the HNSC breakdown →