AKR1D1

Across TCGA patient cohorts, AKR1D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,027 significant associations in total. STAD shows the largest number of these associations.

The most reproducible AKR1D1-associated GO terms across cancer lineages are Regulation of response to endoplasmic reticulum stress, Negative regulation of mitotic cell cycle phase transition, and Negative regulation of leukocyte apoptotic process. Each is linked with AKR1D1 in more than 14 cancer types. Because this analysis shows association rather than direction, both AKR1D1-to-partner and partner-to-AKR1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of response to endoplasmic reticulum stress grouped by AKR1D1-low versus AKR1D1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1D1→partner) and Y-score (partner→AKR1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of response to endoplasmic reticulum stress →	+0.073	+0.197	<.001	<.001	3	15
ESCA	Negative regulation of mitotic cell cycle phase transition →	+0.074	+0.308	<.001	<.001	3	14
STAD	Negative regulation of leukocyte apoptotic process →	+0.070	+0.182	<.001	<.001	3	14
STAD	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum →	+0.067	+0.169	<.001	<.001	3	14
STAD	Aerobic respiration →	+0.073	+0.178	<.001	<.001	3	14
STAD	Monosaccharide metabolic process →	+0.059	+0.184	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,027 associations by consensus.

Regulation of response to endoplasmic reticulum stress by AKR1D1 expression — STAD

Explore this box plot interactively →