AKR1D1

Across TCGA cell cohorts, AKR1D1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,686 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible AKR1D1-associated genes across cancer lineages are AKR1C3, AKR1C1, and AKR1C2. Each is linked with AKR1D1 in more than 7 cancer types. Because this analysis shows association rather than direction, both AKR1D1-to-partner and partner-to-AKR1D1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKR1D1 versus AKR1C3 in OESOPHAGUS, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1D1→partner) and Y-score (partner→AKR1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AKR1C3 →	+3.936	+3.878	<.001	<.001	3	8
LUNG_SCLC	AKR1C1 →	+6.243	+3.686	.003	.006	3	6
OVARY	AKR1C2 →	+5.450	+2.140	<.001	.004	2	6
LUNG_NSCLC_LUAD	PGD →	+1.663	+3.347	<.001	<.001	3	5
CNS	SLC7A11 →	+2.191	+1.813	.001	<.001	3	5
CNS	PMCH →	-0.231	-1.615	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,686 associations by consensus.

AKR1D1 vs AKR1C3 — OESOPHAGUS

Explore this scatter interactively →