Across TCGA pan-cancer cohorts, AKR1C4 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated AKR1C4 data layer compared with 20 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AKR1C4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AKR1C4 expression acts as an unfavorable survival marker.

KIRP and SARC are the cancer types where AKR1C4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.272	0.885	<.001	12	view →
SARC	DFS	Median	All	0.095	0.632	.002	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: AKR1C4 tumor-vs-normal RNA expression · all AKR1C4 data types