Across TCGA patient cohorts, AKR1C4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,989 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKR1C4-associated proteins across cancer lineages are AKR1C3, GCLC_S8, and SRXN1. Each is linked with AKR1C4 in more than 5 cancer types. Because this analysis shows association rather than direction, both AKR1C4-to-partner and partner-to-AKR1C4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C4→partner) and Y-score (partner→AKR1C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.888	+2.078	<.001	<.001	3	6
LSCC	GCLC_S8 →	+1.463	+1.743	<.001	<.001	3	5
LSCC	SRXN1 →	+1.668	+2.112	<.001	<.001	3	4
UCEC	AKR1C2 →	+2.096	+0.820	<.001	<.001	3	4
LSCC	AKR1C3_S129 →	+2.202	+1.730	<.001	<.001	3	4
LSCC	ALDH3A1 →	+1.864	+1.636	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,989 associations by consensus.

Exploration

AKR1C4 survival (RNA) · tumor vs normal (RNA) · all AKR1C4 data types