Across TCGA patient cohorts, AKR1C4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,568 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKR1C4-associated genes across cancer lineages are AKR1C3, AKR1B10, and GUCY2EP. Each is linked with AKR1C4 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKR1C4-to-partner and partner-to-AKR1C4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C4→partner) and Y-score (partner→AKR1C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AKR1C3 →	+3.829	+1.152	.003	.006	3	4
LUAD	AKR1B10 →	+4.302	+1.331	<.001	<.001	3	4
HNSC	GUCY2EP →	+1.855	+1.474	<.001	<.001	3	4
HNSC	CYP4F3 →	+4.598	+1.423	<.001	.005	3	3
LSCC	AKR1C2 →	+3.587	+1.320	<.001	<.001	3	3
LUAD	NQO1 →	+2.604	+1.537	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,568 associations by consensus.

Exploration

AKR1C4 survival (RNA) · tumor vs normal (RNA) · all AKR1C4 data types