Across TCGA patient cohorts, AKR1C4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C4-associated genes across cancer lineages are TFRC, JNK_pT183_Y185, and JNK2. Each is linked with AKR1C4 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKR1C4-to-partner and partner-to-AKR1C4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C4→partner) and Y-score (partner→AKR1C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.645	+3.169	.004	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.181	-2.209	.011	.011	3	1
UCEC	JNK2 →	+0.201	+3.026	.017	.018	3	1
UCEC	Notch1 →	+0.177	+2.222	.002	.011	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.441	-1.687	.021	.044	3	1
UCEC	p62 Lck ligand →	+0.306	+3.169	.026	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

AKR1C4 survival (RNA) · tumor vs normal (RNA) · all AKR1C4 data types