Across TCGA cell cohorts, AKR1C4 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AKR1C4-associated genes across cancer lineages are SMIM23, GAGE12D, and GAGE12C. Each is linked with AKR1C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C4-to-partner and partner-to-AKR1C4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C4→partner) and Y-score (partner→AKR1C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SMIM23 →	+0.020	+4.643	<.001	.008	3	1
OVARY	GAGE12D →	+0.440	+5.807	<.001	.001	3	1
OVARY	GAGE12C →	+0.440	+5.807	<.001	.001	3	1
OVARY	CD300H →	+0.065	+5.196	<.001	.005	3	1
LUNG_NSCLC_LUAD	LYZL1 →	+0.014	+3.150	.002	.006	3	1
LUNG_NSCLC_LUAD	CELA1 →	+0.084	+3.594	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

AKR1C4 survival (RNA) · tumor vs normal (RNA) · all AKR1C4 data types