Across TCGA patient cohorts, AKR1C3 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,670 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AKR1C3-associated proteins across cancer lineages are AKR1C3_S129, AKR1B10, and AKR1C1. Each is linked with AKR1C3 in more than 7 cancer types. Because this analysis shows association rather than direction, both AKR1C3-to-partner and partner-to-AKR1C3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C3→partner) and Y-score (partner→AKR1C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3_S129 →	+2.647	+3.507	<.001	<.001	3	8
LSCC	AKR1B10 →	+2.604	+3.576	<.001	<.001	3	6
LSCC	AKR1C1 →	+2.098	+3.873	<.001	<.001	3	6
LSCC	AKR1C2 →	+1.880	+3.841	<.001	<.001	3	6
LSCC	TKT →	+0.408	+2.689	<.001	<.001	3	5
LSCC	CBR1 →	+0.850	+3.272	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,670 associations by consensus.

Exploration

AKR1C3 survival (RNA) · tumor vs normal (RNA) · all AKR1C3 data types