Across TCGA patient cohorts, AKR1C3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,477 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AKR1C3-associated genes across cancer lineages are AKR1C2, AKR1C1, and AKR1B10. Each is linked with AKR1C3 in more than 8 cancer types. Because this analysis shows association rather than direction, both AKR1C3-to-partner and partner-to-AKR1C3 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C3→partner) and Y-score (partner→AKR1C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C2 →	+3.960	+2.108	<.001	<.001	3	9
LSCC	AKR1C1 →	+3.862	+2.010	<.001	<.001	3	8
LSCC	AKR1B10 →	+3.987	+1.973	<.001	<.001	3	7
LSCC	ALDH3A1 →	+3.115	+1.689	<.001	<.001	3	6
LSCC	AKR1C4 →	+2.078	+1.888	<.001	<.001	3	6
LSCC	DNAJB3 →	+2.313	+1.711	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,477 associations by consensus.

Exploration

AKR1C3 survival (RNA) · tumor vs normal (RNA) · all AKR1C3 data types