Across TCGA patient cohorts, AKR1C3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C3-associated genes across cancer lineages are Bax, NF-kB-p65_pS536, and EGFR_pY1068. Each is linked with AKR1C3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C3-to-partner and partner-to-AKR1C3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C3→partner) and Y-score (partner→AKR1C3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.223	+2.179	.033	.034	3	2
SKCM	NF-kB-p65_pS536 →	-0.413	-3.000	.014	.034	3	2
UCEC	EGFR_pY1068 →	-0.249	-3.169	.023	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.130	-3.312	.017	.010	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.473	+2.179	.033	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.226	-3.169	.002	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

AKR1C3 survival (RNA) · tumor vs normal (RNA) · all AKR1C3 data types