Across TCGA patient cohorts, AKR1C1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,109 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKR1C1-associated genes across cancer lineages are AKR1C2, AKR1C3, and RPL17P11. Each is linked with AKR1C1 in more than 5 cancer types. Because this analysis shows association rather than direction, both AKR1C1-to-partner and partner-to-AKR1C1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C1→partner) and Y-score (partner→AKR1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C2 →	+3.990	+2.237	<.001	<.001	3	6
LSCC	AKR1C3 →	+3.873	+2.098	<.001	<.001	3	6
LSCC	RPL17P11 →	+2.620	+2.118	<.001	<.001	3	5
LSCC	GCLM →	+1.766	+1.875	<.001	<.001	3	5
LSCC	GCLC →	+1.958	+1.814	<.001	<.001	3	4
LSCC	TRIM16L →	+2.305	+2.149	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,109 associations by consensus.

Exploration

AKR1C1 survival (RNA) · tumor vs normal (RNA) · all AKR1C1 data types