AKR1B1P7

Across TCGA pan-cancer cohorts, AKR1B1P7 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of AKR1B1P7’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where AKR1B1P7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKR1B1P7 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BLCA, BRCA, and KICH are the cancer types where AKR1B1P7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR1B1P7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.067	.006	6	view →
BRCA	All	All	−0.020	.013	4	view →
KICH	All	All	−0.171	.001	3	view →
PRAD	All	All	−0.078	.001	2	view →
HNSC	All	III,IV	+0.031	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

AKR1B1P7–BLCA

Open the BLCA breakdown →