AKR1B1P1

Across TCGA pan-cancer cohorts, AKR1B1P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of AKR1B1P1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AKR1B1P1 RNA is repressed in tumor relative to normal tissue. In most cancer types AKR1B1P1 is over-expressed in tumor, although a few such as KICH and PRAD show the opposite, repressed pattern.

KICH, KIRP, and PRAD are the cancer types where AKR1B1P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR1B1P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.100	<.001	5	view →
KIRP	All	II,III,IV	+0.066	.016	2	view →
PRAD	All	All	−0.045	.034	2	view →
BRCA	All	III,IV	−0.025	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

AKR1B1P1–KICH

Open the KICH breakdown →