Across TCGA patient cohorts, AKR1B15 mutation is significantly associated with the RNA expression of many other genes, with 2,766 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1B15-associated genes across cancer lineages are RN7SKP188, POM121C, and OR5D3P. Each is linked with AKR1B15 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKR1B15-to-partner and partner-to-AKR1B15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B15→partner) and Y-score (partner→AKR1B15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RN7SKP188 →	+0.170	+5.149	<.001	.001	3	3
UCEC	POM121C →	+0.427	+2.724	<.001	.003	3	2
COAD	OR5D3P →	+0.040	+4.332	.007	.006	3	2
COAD	RNU6-1127P →	+0.566	+4.136	<.001	.008	3	2
COAD	RNA5SP86 →	+0.723	+4.557	<.001	.004	3	2
COAD	HMGN2P32 →	+0.705	+3.852	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,766 associations by consensus.

Exploration

AKR1B15 survival (RNA) · tumor vs normal (RNA) · all AKR1B15 data types