Across TCGA patient cohorts, AKR1B15 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1B15-associated genes across cancer lineages are FoxM1, Annexin_VII, and Cyclin-B1. Each is linked with AKR1B15 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKR1B15-to-partner and partner-to-AKR1B15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B15→partner) and Y-score (partner→AKR1B15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.224	+1.700	.041	.044	3	3
UCEC	Annexin_VII →	-0.119	-1.700	.044	.044	3	3
UCEC	Cyclin-B1 →	+0.785	+3.321	<.001	.010	3	3
UCEC	Akt_pT308 →	+0.525	+2.999	.049	.035	3	2
UCEC	PCNA →	+0.202	+1.700	.027	.044	3	2
UCEC	ASNS →	+0.542	+3.321	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

AKR1B15 survival (RNA) · tumor vs normal (RNA) · all AKR1B15 data types