Across TCGA cell cohorts, AKR1B15 mutation is significantly associated with the RNA expression of many other genes, with 148 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AKR1B15-associated genes across cancer lineages are TREML4, KRT2, and MUC19. Each is linked with AKR1B15 in more than 2 cancer types. Because this analysis shows association rather than direction, both AKR1B15-to-partner and partner-to-AKR1B15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B15→partner) and Y-score (partner→AKR1B15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TREML4 →	+0.183	+4.087	<.001	<.001	3	3
LIVER	KRT2 →	+0.087	+3.984	.001	<.001	3	2
LIVER	MUC19 →	+0.379	+3.321	.001	.006	3	2
KIDNEY	ASIC5 →	+0.114	+3.736	<.001	.002	3	2
LUNG_NSCLC_LUAD	OR13H1 →	+0.049	+2.791	.001	.003	3	2
LUNG_NSCLC_LUAD	AKR1C4 →	+0.632	+3.603	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 148 associations by consensus.

Exploration

AKR1B15 survival (RNA) · tumor vs normal (RNA) · all AKR1B15 data types