Across TCGA pan-cancer cohorts, AKR1B10 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AKR1B10’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where AKR1B10 RNA is repressed in tumor relative to normal tissue. In most cancer types AKR1B10 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.
COAD, KIRP, and LUSC are the cancer types where AKR1B10 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR1B10 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.