Across TCGA pan-cancer cohorts, AKR1B10 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of AKR1B10’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AKR1B10 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types AKR1B10 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD and LSCC are the cancer types where AKR1B10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR1B10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.950	<.001	12	view →
LSCC	All	II,III,IV	+1.813	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: AKR1B10 RNA expression & survival · all AKR1B10 data types