AKR1B1

Across TCGA pan-cancer cohorts, AKR1B1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated AKR1B1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AKR1B1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated AKR1B1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

UCEC, COAD, and LUAD are the cancer types where AKR1B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.822	0.982	.001	32	view →
COAD	DFS	Quartile	II,III,IV	0.818	1.000	.024	30	view →
LUAD	OS	Median	II,III,IV	0.854	0.474	.026	5	view →
LSCC	OS	Median	All	0.767	1.000	.015	4	view →
PDAC	OS	Quartile	All	0.971	0.783	.013	3	view →
CCRCC	OS	Median	III,IV	1.000	0.842	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

AKR1B1–UCEC (OS)

Open the UCEC breakdown →