AKR1B1

Across TCGA patient cohorts, AKR1B1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,478 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKR1B1-associated proteins across cancer lineages are ALOX5, IFI30, and THEMIS2_T593. Each is linked with AKR1B1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AKR1B1-to-partner and partner-to-AKR1B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKR1B1 versus ALOX5 in UCEC, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B1→partner) and Y-score (partner→AKR1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALOX5 →	+0.554	+0.926	<.001	.004	3	5
GBM	IFI30 →	+0.807	+0.465	<.001	<.001	3	5
UCEC	THEMIS2_T593 →	+0.684	+1.005	<.001	<.001	3	5
LSCC	UCHL1 →	+0.984	+0.630	<.001	<.001	3	5
GBM	CD14 →	+0.580	+0.373	.002	.002	3	4
GBM	CD163 →	+0.733	+0.352	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,478 associations by consensus.

AKR1B1 vs ALOX5 — UCEC

Explore this scatter interactively →