AKR1B1

Across TCGA patient cohorts, AKR1B1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,847 significant associations in total. COAD shows the largest number of these associations.

The most reproducible AKR1B1-associated genes across cancer lineages are ACSM5, SIGLEC8, and BTK. Each is linked with AKR1B1 in more than 7 cancer types. Because this analysis shows association rather than direction, both AKR1B1-to-partner and partner-to-AKR1B1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AKR1B1 versus ACSM5 in GBM, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B1→partner) and Y-score (partner→AKR1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ACSM5 →	+0.831	+0.313	<.001	<.001	3	8
GBM	SIGLEC8 →	+0.970	+0.195	<.001	.006	3	7
UCEC	BTK →	+0.953	+0.494	<.001	<.001	3	7
GBM	KCNJ5 →	+1.021	+0.330	<.001	<.001	3	7
BRCA	MS4A7 →	+1.228	+0.428	<.001	<.001	3	7
BRCA	GPR34 →	+1.111	+0.549	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,847 associations by consensus.

AKR1B1 vs ACSM5 — GBM

Explore this scatter interactively →