AKR1B1

Across TCGA patient cohorts, AKR1B1 mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1B1-associated genes across cancer lineages are SNORD116-16, PACSIN2, and BAG1. Each is linked with AKR1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1B1-to-partner and partner-to-AKR1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-16 grouped by AKR1B1-low versus AKR1B1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B1→partner) and Y-score (partner→AKR1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	SNORD116-16 →	+0.454	+4.653	<.001	.007	3	2
UCEC	PACSIN2 →	+0.515	+3.584	.007	.003	3	2
UCEC	BAG1 →	+0.492	+3.219	.008	.009	3	2
UCEC	ACADS →	+0.750	+3.595	.001	.001	3	2
UCEC	NF2 →	+0.596	+3.483	.001	.002	3	2
UCEC	TOP3A →	+0.543	+3.584	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

SNORD116-16 by AKR1B1 expression — READ

Explore this box plot interactively →