AKR1B1

Across TCGA patient cohorts, AKR1B1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1B1-associated genes across cancer lineages are p27_pT198, Fibronectin, and Tuberin. Each is linked with AKR1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1B1-to-partner and partner-to-AKR1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by AKR1B1-low versus AKR1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B1→partner) and Y-score (partner→AKR1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.140	+3.169	.016	.020	3	2
UCEC	Fibronectin →	-0.360	-3.169	.047	.020	3	1
UCEC	Tuberin →	+0.375	+3.169	.011	.020	3	1
UCEC	ERK2 →	+0.367	+3.169	<.001	.020	1	2
UCEC	JNK2 →	+0.374	+2.817	<.001	.036	2	1
UCEC	MEK1 →	+0.527	+3.169	.008	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

p27_pT198 by AKR1B1 expression — UCEC

Explore this box plot interactively →