AKR1B1

Across TCGA cell cohorts, AKR1B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,410 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible AKR1B1-associated GO terms across cancer lineages are Hyperosmotic salinity response, Cellular hyperosmotic salinity response, and Cellular response to salt stress. Each is linked with AKR1B1 in more than 14 cancer types. Because this analysis shows association rather than direction, both AKR1B1-to-partner and partner-to-AKR1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hyperosmotic salinity response grouped by AKR1B1-low versus AKR1B1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B1→partner) and Y-score (partner→AKR1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Hyperosmotic salinity response →	+0.249	+2.420	<.001	<.001	3	15
BONE	Cellular hyperosmotic salinity response →	+0.249	+2.420	<.001	<.001	3	15
LIVER	Cellular response to salt stress →	+0.323	+3.661	<.001	<.001	3	12
LIVER	Response to salt stress →	+0.309	+3.342	<.001	.001	3	12
BONE	C21-steroid hormone biosynthetic process →	+0.313	+1.886	<.001	.002	3	11
OVARY	Polyketide metabolic process →	+0.228	+2.428	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,410 associations by consensus.

Hyperosmotic salinity response by AKR1B1 expression — BONE

Explore this box plot interactively →