AKR1A1

Across TCGA patient cohorts, AKR1A1 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1A1-associated genes across cancer lineages are PREX1, p62 Lck ligand, and Rad50. Each is linked with AKR1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1A1-to-partner and partner-to-AKR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PREX1 grouped by AKR1A1-low versus AKR1A1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1A1→partner) and Y-score (partner→AKR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PREX1 →	-0.368	-3.000	.049	.035	3	1
UCEC	p62 Lck ligand →	+0.391	+3.459	.016	.005	3	1
UCEC	Rad50 →	-0.311	-3.459	.010	.005	3	1
UCEC	Annexin-1 →	+0.642	+2.827	.015	.035	3	1
UCEC	Src_pY527 →	-0.460	-2.990	.033	.036	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.604	-3.169	.007	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PREX1 by AKR1A1 expression — SKCM

Explore this box plot interactively →