AKR1A1

Across TCGA cell cohorts, AKR1A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,652 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AKR1A1-associated GO terms across cancer lineages are Glutathione derivative biosynthetic process, Dentinogenesis, and Non-proteinogenic amino acid metabolic process. Each is linked with AKR1A1 in more than 9 cancer types. Because this analysis shows association rather than direction, both AKR1A1-to-partner and partner-to-AKR1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glutathione derivative biosynthetic process grouped by AKR1A1-low versus AKR1A1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1A1→partner) and Y-score (partner→AKR1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Glutathione derivative biosynthetic process →	+0.214	+0.897	<.001	<.001	3	10
BONE	Dentinogenesis →	-1.840	-0.770	<.001	.003	3	9
CNS	Non-proteinogenic amino acid metabolic process →	+0.064	+0.463	<.001	.002	3	7
LUNG_NSCLC_LUAD	Regulation of coagulation →	-0.110	-0.768	<.001	<.001	3	7
BLOOD_Lymphoma	CAMKK-AMPK signaling cascade →	+0.128	+0.519	<.001	.001	3	7
LARGE_INTESTINE	Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA →	+0.075	+0.458	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,652 associations by consensus.

Glutathione derivative biosynthetic process by AKR1A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →